Key result
During spreading of cardiac myocytes, myofibrils form at the cell periphery behind extending margins, with aggregates of alpha-actinin acting as nascent Z bands.
Population
Cardiac myocytes isolated from 5-6-day-old chick embryos
Design
Preclinical
Follow-up
5 days
Authors
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Hypothesis-generating for myofibrillogenesis in spreading myocytes; clinical relevance remains untested.
This preclinical study elucidates the mechanism of myofibril assembly in spreading cardiac myocytes, identifying alpha-actinin aggregates as nascent Z bands at the cell periphery.
Sanger et al. (1984) studied Spreading chick cardiac myocytes. Rhodamine-labeled alpha-actinin and fluorescein-labeled heavy meromyosin was evaluated on Distribution of alpha-actinin and formation of myofibrils. During spreading of cardiac myocytes, myofibrils form at the cell periphery behind extending margins, with aggregates of alpha-actinin acting as nascent Z bands.
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