Population
Freshly isolated cat and rat adult cardiomyocytes
Design
Preclinical
Authors
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Suggests mechanism for fetal protein re-expression in hypertrophy; hypothesis-generating and requires in vivo validation.
Adult mammalian cardiomyocytes re-express the embryonic program for myofibrillogenesis when spreading in culture, providing a potential cellular mechanism for the reinitiation of fetal sarcomeric proteins observed in hypertrophic hearts.
LoRusso et al. (1997) studied this question.
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