Key result
Untreated pre-eclampsia was associated with increased cardiac output (4789 vs 4109 ml/min; p=0.002) and systemic vascular resistance (2016 vs 1613 dyne.s.cm-5; p=0.001) compared to healthy pregnancy.
Population
100 women (40 with untreated pre-eclampsia, 40 matched healthy pregnant women, and 20 non-pregnant women)
Design
Cross-sectional
Authors
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Highlights combined high-output vasoconstriction in untreated pre-eclampsia; extends pathophysiology understanding but leaves open outcome prediction and management trials.
Cross-Sectional (n=100)
Absolute Event Rate: 4789% vs 4109%
p-value: p=0.002
Hypertension in untreated pre-eclampsia is driven by increased cardiac output and mild vasoconstriction, accompanied by increased inotropy and reduced diastolic function.
Dennis et al. (2012) conducted a cross-sectional in Untreated pre-eclampsia (n=100). Untreated pre-eclampsia vs. Healthy pregnant and non-pregnant women was evaluated on Cardiac output (ml/min) (p=0.002). Untreated pre-eclampsia was associated with increased cardiac output (4789 vs 4109 ml/min; p=0.002) and systemic vascular resistance (2016 vs 1613 dyne.s.cm-5; p=0.001) compared to healthy pregnancy.
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