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August 20, 2013HypertensionOpen Access

Diminazene Aceturate Enhances Angiotensin-Converting Enzyme 2 Activity and Attenuates Ischemia-Induced Cardiac Pathophysiology

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Why the study?

Does Diminazene aceturate improve cardiac function and attenuate remodeling in a rat model of myocardial infarction?

Population

Rat model of myocardial infarction (MI rats)

Comparison

Diminazene aceturate 15 mg/kg per day… vs Control, DIZE alone, and MI without DIZE treatment

Design

Preclinical

Authors

YQYanfei QiDuquesne UniversityJZJuan ZhangInstitute of Quality Standards and Testing Technology for Agro ProductsCCColleen T. Cole‐JeffreyRenji Hospital

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Implication

Supports ACE2 activation post-MI in rats; leaves open human translation.

Structured PICO

Does Diminazene aceturate improve cardiac function and attenuate remodeling in a rat model of myocardial infarction?

P
Population
Rat model of myocardial infarction (MI rats)
I
Intervention
Diminazene aceturate (DIZE) 15 mg/kg per day, subcutaneous, starting 2 days before MI surgery and continued throughout the study period
C
Comparator
Control (no MI), DIZE alone, and MI without DIZE treatment
O
Outcome
Cardiac function (fractional shortening, contractility) and ventricular hypertrophysurrogate

Activation of ACE2 by diminazene aceturate attenuates left ventricular remodeling and improves cardiac function post-myocardial infarction in rats.

Cite This Study

Qi et al. (2013) studied this question.

synapsesocial.com/papers/6a2017dea05ff06c2ba1a3eahttps://doi.org/10.1161/hypertensionaha.113.01337
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating Rather Than Cardiac Angiotensin-(1-7) Stimulates Cardioprotection After Myocardial Infarction2010 · 82 citations
  2. 2Coronary Vascular Remodeling and Myocardial Fibrosis in the Rat with Renovascular Hypertension Response to Captopril1991 · 98 citations
  3. 3Counterregulatory Actions of Angiotensin-(1-7)1997 · 510 citations
  4. 4A Human Homolog of Angiotensin-converting Enzyme2000 · 2,047 citations
  5. 5Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo2009 · 72 citations