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October 13, 2015Protein and Peptide Letters

Anti-hypertensive Effects of Diminazene Aceturate: An Angiotensin- Converting Enzyme 2 Activator in Rats

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Why the study?

Does diminazene aceturate reduce blood pressure in normotensive and hypertensive rats?

Population

Conscious normotensive and hypertensive rats (renovascular model of hypertension) and isolated vessels

Comparison

Diminazene aceturate, an angiotensin-converting… vs Captopril; A-779 and L-NAME

Design

Preclinical

Authors

MMMarilda L.A. De MariaUniversidade Federal de Minas GeraisLALiliane D. AraújoRFRodrigo A. Fraga-SilvaSaab (Switzerland)

Discussion

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Implication

DIZE lowers BP in hypertensive rats; leaves open whether ACE2 activation benefits humans.

Structured PICO

Does diminazene aceturate reduce blood pressure in normotensive and hypertensive rats?

P
Population
Conscious normotensive and hypertensive rats (renovascular model of hypertension) and isolated vessels
I
Intervention
Diminazene aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator
C
Comparator
Captopril (in hypertensive rats); A-779 and L-NAME (in mechanistic studies)
O
Outcome
Blood pressure (BP) and heart rate (HR)surrogate

The ACE2 activator diminazene aceturate effectively reduces blood pressure and prevents cardiac hypertrophy in hypertensive rats via a Mas- and NO-dependent mechanism.

Cite This Study

Maria et al. (2015) studied this question.

synapsesocial.com/papers/6a6fb6516ceb2bbd16dfb793https://doi.org/10.2174/0929866522666151013130550
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor2020 · 21 citations
  2. 2Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension2019 · 9 citations
  3. 3Diminazene Aceturate Is an ACE2 Activator and a Novel Antihypertensive Drug2010 · 22 citations
  4. 4Diminazene Aceturate (DIZE) Ameliorates Hypertension and Induces Anxiolytic- and Antidepressant-like Effects in TGR(mRen2)272025 · 6 citations
  5. 5Short-Term Treatment with Diminazene Aceturate Ameliorates the Reduction in Kidney ACE2 Activity in Rats with Subtotal Nephrectomy2015 · 48 citations