Key result
Oral administration of the ACE2 activator DIZE for 4 weeks in 2K1C hypertensive rats attenuated renal dysfunction and reduced levels of inflammatory markers.
Why the study?
Very few studies have investigated the role of components of the counterregulatory RAS axis in renovascular hypertension, and the existing results remain controversial.
Does Diminazene Aceturate improve renal function and inflammation in a rat model of renovascular hypertension?
Population
Male Wistar rats
Comparison
2K1C+DIZE (1 mg/kg/day orally) vs 2K1C+saline vs sham-operated animals
Design
Animal experimental study
Follow-up
30 days
Authors
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May support ACE2 activation for renal protection in hypertension models; hypothesis-generating for clinical translation.
Does Diminazene Aceturate improve renal function and inflammation in a rat model of renovascular hypertension?
In a rat model of renovascular hypertension, ACE2 activation with Diminazene Aceturate attenuated renal dysfunction and inflammation.
Kangussu et al. (2019) studied Renovascular hypertension. Diminazene Aceturate (DIZE) vs. sham-operated animals and 2K1C+saline was evaluated on renal function and renal inflammation parameters. Oral administration of the ACE2 activator DIZE for 4 weeks in 2K1C hypertensive rats attenuated renal dysfunction and reduced levels of inflammatory markers.
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