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July 4, 2016Current Opinion in Nephrology & Hypertension

Angiotensin converting enzyme 2 and diminazene

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Key result

Diminazene aceturate (DIZE) activates ACE2 and demonstrates beneficial effects in experimental models of cardiovascular disease, though clinical studies are unlikely due to its toxicity.

Population

Experimental models of cardiovascular disease

Design

Review

Authors

EVElena VelkoskaCSL (Australia)SPSheila K. PatelThe University of MelbourneLBLouise M. BurrellHeart Failure & Transplant

Discussion

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Implication

Supports ACE2 activation via diminazene for CV protection; extends experimental data, warranting clinical trials.

Structured PICO

P
Population
Experimental models of cardiovascular disease (hypertension, pulmonary hypertension, myocardial infarction, stroke, atherosclerosis, type 1 diabetes, and eye disease)
I
Intervention
Diminazene aceturate (DIZE)

Diminazene aceturate demonstrates the therapeutic potential of ACE2 activation in experimental cardiovascular models, though its toxicity necessitates the development of safer alternatives for clinical use.

Limitations

  • There are no clinical studies of DIZE, and its side-effects and toxicity make such studies unlikely.
  • The precise mechanism of action of DIZE to activate ACE2 remains under scrutiny.
  • No clinical studies of DIZE
  • Side-effects and toxicity make clinical studies unlikely
  • Precise mechanism of action remains under scrutiny

Cite This Study

Velkoska et al. (2016) conducted a review in Cardiovascular disease. Diminazene aceturate (DIZE) was evaluated. Diminazene aceturate (DIZE) activates ACE2 and demonstrates beneficial effects in experimental models of cardiovascular disease, though clinical studies are unlikely due to its toxicity.

synapsesocial.com/papers/6a5bbc8e9b5d0f06daf79c6ehttps://doi.org/10.1097/mnh.0000000000000254

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short-Term Treatment with Diminazene Aceturate Ameliorates the Reduction in Kidney ACE2 Activity in Rats with Subtotal Nephrectomy2015 · 48 citations
  2. 2Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury2014 · 27 citations
  3. 3Antiglaucomatous Effects of the Activation of Intrinsic Angiotensin-Converting Enzyme 22013 · 74 citations
  4. 4Angiotensin-Converting Enzyme 2–Independent Action of Presumed Angiotensin-Converting Enzyme 2 Activators2014 · 116 citations
  5. 5Angiotensin-Converting Enzyme 2 Decreases Formation and Severity of Angiotensin II–Induced Abdominal Aortic Aneurysms2014 · 50 citations