Key result
Diminazene aceturate treatment reduced diabetes-induced renal damage, fibrosis, and apoptosis in a rat model of type 1 diabetes, effects that were blocked by an AT2 receptor antagonist.
Why the study?
Does diminazene aceturate prevent renal damage in a rat model of type 1 diabetes?
Population
Male Wistar rats rendered diabetic using a single dose of streptozotocin (55 mg/kg, i.p.)
Comparison
Diminazene aceturate at low dose, high dose, or… vs Untreated diabetic rats
Design
Preclinical
Authors
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DIZE may attenuate diabetic nephropathy in preclinical models; leaves open clinical translation of ACE2 activation.
Does diminazene aceturate prevent renal damage in a rat model of type 1 diabetes?
In a rat model of type 1 diabetes, the ACE2 activator diminazene aceturate protected against diabetic nephropathy via the ACE2/angiotensin-(1-7)/AT2 receptor axis.
Goru et al. (2017) studied Diabetic nephropathy (type 1 diabetes). Diminazene aceturate (DIZE) vs. Diabetic control / PD123319 co-treatment was evaluated on Renal damage (fibrosis and apoptosis), ACE2 and AT2 receptor expression. Diminazene aceturate treatment reduced diabetes-induced renal damage, fibrosis, and apoptosis in a rat model of type 1 diabetes, effects that were blocked by an AT2 receptor antagonist.
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