Key result
Chronic administration of diminazene aceturate at 15 mg/kg/day for three weeks in spontaneously hypertensive rats decreased mean arterial pressure from 136 to 124 mmHg (p<0.05).
Why the study?
Does diminazene aceturate reduce mean arterial pressure in spontaneously hypertensive rats?
Population
Wistar-Kyoto (WKY) rats (n=6) and Spontaneously Hypertensive Rats (SHRs) (n=6)
Comparison
Diminazene aceturate administered intravenously… vs Control (untreated or vehicle)
Design
Preclinical
Follow-up
3 weeks
Authors
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No immediate clinical role for DIZE in CVD; leaves open ACE2 activation as a research target for hypertension.
Does diminazene aceturate reduce mean arterial pressure in spontaneously hypertensive rats?
Absolute Event Rate: 124% vs 136%
p-value: p=<0.05
Diminazene aceturate acts as a potent ACE2 activator that reduces blood pressure and cardiac hypertrophy in spontaneously hypertensive rats, suggesting potential as a novel antihypertensive agent.
Gjymishka et al. (2010) studied Hypertension (animal model). Diminazene aceturate (DIZE) vs. Control / Baseline was evaluated on Mean arterial pressure (MAP) (p=<0.05). Chronic administration of diminazene aceturate at 15 mg/kg/day for three weeks in spontaneously hypertensive rats decreased mean arterial pressure from 136 to 124 mmHg (p<0.05).
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