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February 25, 2025Protein and Peptide Letters

Diminazene Aceturate (DIZE) Ameliorates Hypertension and Induces Anxiolytic- and Antidepressant-like Effects in TGR(mRen2)27

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Key result

DIZE lowers blood pressure and attenuates anxiety- and depression-like behaviors in hypertensive rats.

Why the study?

The ACE2/Angiotensin-(1-7)/Mas receptor axis has protective cardiovascular actions and modulates mood and anxiety disorders, motivating evaluation of central DIZE infusion in hypertensive transgenic rats.

Does chronic ICV treatment with DIZE reduce blood pressure and anxiety/depression-like behaviors in hypertensive transgenic rats?

Population

Male 10-12 weeks old TGR and Sprague-Dawley rats

Comparison

Chronic ICV infusion of DIZE (1.0 μg/h)

Design

Animal experimental study

Follow-up

7 days

Authors

LCLaura Amado CostaUniversidade Federal de Minas GeraisFMFlávio Afonso Gonçalves MourãoUniversidade Federal de Minas GeraisNANatália AleninaVascular Medicine

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Implication

Hypothesis-generating for central ACE2 activation in hypertension with mood symptoms; leaves open human translation.

Structured PICO

Does chronic ICV treatment with DIZE reduce blood pressure and anxiety/depression-like behaviors in hypertensive transgenic rats?

P
Population
Male hypertensive transgenic (mRen2)27 rats and Sprague-Dawley rats (10-12 weeks old) treated with chronic ICV infusion of DIZE for 7 days.
I
Intervention
Diminazene aceturate (DIZE) 1.0 μg/h via chronic intracerebroventricular (ICV) infusion for 7 days
O
Outcome
Blood pressure, heart rate, and anxiety- and depression-like behaviors (evaluated through elevated plus maze, marble burying and forced swim tests)surrogate

Central administration of the ACE2 activator DIZE reduces blood pressure and improves anxiety and depression-like behaviors in a hypertensive rat model.

Cite This Study

Costa et al. (2025) studied Hypertension, anxiety, and depression. Diminazene aceturate (DIZE) was evaluated on Blood pressure, heart rate, anxiety- and depression-like behaviors. Chronic intracerebroventricular infusion of diminazene aceturate (DIZE) significantly reduced mean arterial pressure and attenuated anxiety- and depression-like behaviors in hypertensive rats.

synapsesocial.com/papers/6a20d878dc4e16663149cb62https://doi.org/10.2174/0109298665357730250213050214

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-hypertensive Effects of Diminazene Aceturate: An Angiotensin- Converting Enzyme 2 Activator in Rats2015 · 56 citations
  2. 2Diminazene Aceturate Is an ACE2 Activator and a Novel Antihypertensive Drug2010 · 22 citations
  3. 3Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT<sub>2</sub> receptor expression in a rat model of type1 diabetes2017 · 72 citations
  4. 4The potential actions of angiotensin‐converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases2020 · 102 citations
  5. 5Activation of angiotensin-converting enzyme 2 improves cardiac electrical changes in ventricular repolarization in streptozotocin-induced hyperglycaemic rats2014 · 28 citations