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June 30, 2020Clinical and Experimental Pharmacology and Physiology

Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor

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Why the study?

Diminazene aceturate has been described as an ACE2 activator, but its effects on blood pressure in hypertensive and normotensive models required investigation.

Population

Spontaneously hypertensive rats and Wistar Kyoto rats

Comparison

Diminazene aceturate with or without L-NAME or A-779

Design

Preclinical animal and ex vivo study

Authors

CSCarmem Luíza SartórioUniversitat Autònoma de BarcelonaEPEnildo Broetto PimentelUniversidade Federal do Espírito SantoRSRoger Lyrio dos SantosUniversidade Federal do Espírito Santo

Discussion

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Implication

Hypothesis-generating in hypertensive rat models; human studies needed before any clinical consideration.

Structured PICO

P
Population
Spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats
I
Intervention
Diminazene aceturate (DIZE) 15 mg/kg s.c., with or without pre-treatment with L-NAME (10 mg/kg iv) or A-779 (50 ug/kg iv); in vitro DIZE (10^-9 to 10^-4 mol/L)
C
Comparator
WKY rats (normotensive controls) and baseline/vehicle
O
Outcome
Blood pressure (BP) changessurrogate

Diminazene aceturate acutely reduces blood pressure in spontaneously hypertensive rats through a nitric oxide-mediated mechanism rather than Mas receptor activation.

Cite This Study

Sartório et al. (2020) studied this question.

synapsesocial.com/papers/6a82a937e41271e79b8d5e2fhttps://doi.org/10.1111/1440-1681.13368

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diminazene Aceturate Enhances Angiotensin-Converting Enzyme 2 Activity and Attenuates Ischemia-Induced Cardiac Pathophysiology2013 · 131 citations
  2. 2Angiotensin-(1–7) Acts as a Vasodepressor Agent Via Angiotensin II Type 2 Receptors in Conscious Rats2005 · 205 citations
  3. 3Regulation of angiotensin-converting enzyme 2 and Mas receptor by Ang-(1–7) in heart and kidney of spontaneously hypertensive rats2011 · 39 citations
  4. 4NO modulates autonomic effects on sinus discharge rate and AV nodal conduction in open-chest dogs1997 · 83 citations
  5. 5Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas2003 · 1,818 citations