Key result
Spontaneously hypertensive rats had 47% higher cardiac (P<0.05) and 16.5% lower renal (P<0.05) angiotensin-(1-12) levels compared with normotensive Wistar-Kyoto rats.
Population
11-wk-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats (n = 14)
Comparison
Tissue staining with purified antibodies… vs Wistar-Kyoto (WKY) normotensive rats
Design
Preclinical
Authors
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Angiotensin-(1-12) merits study as a local tissue regulator in hypertension; animal data leave open human relevance and therapeutic potential.
Effect estimate: 47% higher in heart, 16.5% lower in kidney
p-value: p=<0.05
Angiotensin-(1-12) is localized in cardiac myocytes and renal tubules, with higher cardiac and lower renal levels in spontaneously hypertensive rats compared to normotensive controls, suggesting a role in local angiotensin production.
Jessup et al. (2008) studied Hypertension (n=14). Spontaneously hypertensive strain vs. Wistar-Kyoto (WKY) normotensive strain was evaluated on Cardiac and renal angiotensin-(1-12) levels (47% higher in heart, 16.5% lower in kidney, p=<0.05). Spontaneously hypertensive rats had 47% higher cardiac (P<0.05) and 16.5% lower renal (P<0.05) angiotensin-(1-12) levels compared with normotensive Wistar-Kyoto rats.
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