Key result
Adrenergic stimulation with isoproterenol or forskolin reversibly stimulated the delayed outward K+ current, an effect reversed by acetylcholine via a pertussis toxin-sensitive G protein pathway.
Population
isolated guinea pig ventricular myocytes
Design
Preclinical
Authors
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May inform autonomic modulation of cardiac repolarization; hypothesis-generating for human arrhythmia mechanisms and therapies.
Autonomic regulation of the delayed rectifier K+ current in the mammalian heart involves guanine nucleotide-binding (G) proteins.
Harvey et al. (1989) studied this question. Isoproterenol, forskolin, and acetylcholine was evaluated on Delayed outward K+ current (IK). Adrenergic stimulation with isoproterenol or forskolin reversibly stimulated the delayed outward K+ current, an effect reversed by acetylcholine via a pertussis toxin-sensitive G protein pathway.
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