Key result
Surgical removal of the clipped kidney and medical therapy with captopril both significantly reduced ventricular weight in renal hypertensive rats (2.70 and 2.78 vs 3.4 mg/g, P<0.01 for both).
Why the study?
Does surgical or medical therapy (captopril) reduce ventricular weight in rats with renovascular hypertension?
Does surgical or medical therapy (captopril) reduce ventricular weight in rats with renovascular hypertension?
Absolute Event Rate: 2.78% vs 3.4%
p-value: p=<0.01
Both surgical nephrectomy and ACE inhibition with captopril effectively reverse cardiac hypertrophy in a rat model of renovascular hypertension.
No takes yet. Share an insight, caveat, or question.
Should not change practice in renovascular hypertension; hypothesis-generating for ACE inhibition or nephrectomy effects on cardiac hypertrophy.
Sen et al. (1981) studied Cardiac hypertrophy consequent to renovascular hypertension. Surgical treatment (removal of clipped kidney) or medical therapy (captopril) vs. Sham control was evaluated on Ventricular weight (p=<0.01). Surgical removal of the clipped kidney and medical therapy with captopril both significantly reduced ventricular weight in renal hypertensive rats (2.70 and 2.78 vs 3.4 mg/g, P<0.01 for both).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: