Key result
Schizophrenia was associated with an indisputable but small difference in ventricle:brain ratio compared to controls, likely too small for practical diagnostic significance.
Why the study?
Is there a difference in ventricle:brain ratio (VBR) between schizophrenics and controls?
Population
39 studies of ventricular size in schizophrenia
Comparison
Schizophrenia vs Controls
Design
Meta-analysis
Authors
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Small VBR differences lack diagnostic utility in schizophrenia; confirms modest structural changes without clinical application.
Meta-Analysis
Is there a difference in ventricle:brain ratio (VBR) between schizophrenics and controls?
While schizophrenics have a different ventricle:brain ratio compared to controls, the difference is too small to be of practical significance in diagnosis.
Horn et al. (1992) conducted a meta-analysis in Schizophrenia. Schizophrenia vs. Controls was evaluated on Ventricle:brain ratio (VBR) difference. Schizophrenia was associated with an indisputable but small difference in ventricle:brain ratio compared to controls, likely too small for practical diagnostic significance.
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