Key result
Schizophrenics without a family history of major psychiatric disorder had significantly increased cerebral ventricular size (P<0.01) compared to those with a family history.
Why the study?
Is cerebral ventricular enlargement associated with non-genetic schizophrenia and birth complications in twins?
Observational
Is cerebral ventricular enlargement associated with non-genetic schizophrenia and birth complications in twins?
Cerebral ventricular enlargement in schizophrenia appears to be associated with non-genetic factors such as birth complications rather than a family history of psychiatric disorders.
Answers are grounded in this paper and cite their sources.
May indicate environmental factors drive ventricular enlargement in non-familial schizophrenia; hypothesis-generating for birth complications, needs prospective confirmation.
In a group of schizophrenics of twin birth, no evidence of ventricular enlargement was found where there was a family history of major psychiatric disorder. Among those schizophrenics without such a family history, cerebral ventricular size was significantly increased (P less than 0.01), and there was also evidence of birth complications. Among normal control twins, those who reported complicated births had significantly larger ventricles.
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Reveley et al. (1984) conducted an observational in Schizophrenia. Absence of family history of major psychiatric disorder vs. Presence of family history of major psychiatric disorder was evaluated on Cerebral ventricular size (p=<0.01). Schizophrenics without a family history of major psychiatric disorder had significantly increased cerebral ventricular size (P<0.01) compared to those with a family history.
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