Almost the entire 5′ non‐translated region of hepatitis C virus is required for cap‐independent translation

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Population

Hepatitis C virus (HCV) 5' untranslated region (5'UTR) constructs

Comparison

Deletion of one or more hairpin structures… vs Wild-type or other hairpin structures

Design

Preclinical

Authors

Discussion

Findings hypothesis-generating for HCV IRES antivirals; leaves open clinical translation pending human validation.

Population

Hepatitis C virus (HCV) 5' untranslated region (5'UTR) constructs

Intervention

Deletion of one or more hairpin structures within the 5'UTR; co-expression of poliovirus 2Apro

Comparator

Wild-type or other hairpin structures

Outcome

Cap-independent translation efficiencysurrogate

Almost all hairpin structures in the HCV 5'UTR are essential for cap-independent translation, which is further stimulated by poliovirus 2Apro.

Rijnbrand et al. (1995) studied this question.

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