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June 1, 1994CirculationOpen Access

Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive patients.

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Key result

Repeated alcohol intake for 7 days in hypertensive men lowered evening systolic BP (126 vs 139 mm Hg) but raised nighttime systolic BP (138 vs 131 mm Hg) compared to a nonalcoholic control.

Why the study?

Does repeated alcohol intake affect 24-hour blood pressure in male habitual drinkers with essential hypertension?

Population

14 male habitual drinkers with essential hypertension

Comparison

Alcohol given at dinner for 7 days vs Nonalcoholic drink with the same calories as…

Design

Cohort

Follow-up

11 days

Authors

HAHitoshi AbeUniversity of ToyamaYKYuhei KawanoPreventive CardiologySKSunao KojimaInterventional Cardiology

Discussion

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Implication

Clinicians should use ABPM to detect alcohol-related nocturnal BP rises in hypertensive men; this cohort finding leaves open causal effects on outcomes.

Structured PICO

Does repeated alcohol intake affect 24-hour blood pressure in male habitual drinkers with essential hypertension?

P
Population
14 male habitual drinkers with essential hypertension evaluated in a sequential 4-day control phase and 7-day alcohol phase.
I
Intervention
Alcohol (ethanol, 1 mL/kg) given at dinner (5 PM to 6 PM) for 7 days
C
Comparator
Nonalcoholic drink with the same calories as alcohol given at dinner for a 4-day control phase
O
Outcome
24-hour ambulatory systolic and diastolic blood pressuresurrogate

Repeated alcohol intake has a biphasic effect on blood pressure in hypertensive patients, with an initial depressor effect followed by a pressor effect hours later, suggesting casual BP measurements may overestimate chronic effects.

Cite This Study

Abe et al. (1994) studied essential hypertension (n=14). Alcohol vs. Nonalcoholic drink with the same calories was evaluated on 24-hour blood pressure. Repeated alcohol intake for 7 days in hypertensive men lowered evening systolic BP (126 vs 139 mm Hg) but raised nighttime systolic BP (138 vs 131 mm Hg) compared to a nonalcoholic control.

synapsesocial.com/papers/6a201d5ec1b320180d0df3bfhttps://doi.org/10.1161/01.cir.89.6.2626

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alcohol and hypertension: new insights from population studies1987 · 48 citations
  2. 2What is the value of home blood pressure measurement in patients with mild hypertension?1984 · 300 citations
  3. 3Alcohol Consumption and Blood Pressure in a Group of Young Australian Males1981 · 13 citations
  4. 4Assessment of Patients With Office Hypertension by 24-Hour Noninvasive Ambulatory Blood Pressure Monitoring1986 · 76 citations
  5. 5Alcohol and the Heart1983 · 53 citations