Key result
Experimentally increasing shear stress via aortic coarctation in rabbits induced rapid F-actin redistribution within 12-24 hours, which reversed slowly over 1 week after coarctation removal.
Population
Rabbits (in vivo endothelial cells)
Comparison
Abdominal aortic coarctation to increase shear… vs Control aortas (normal shear stress)
Design
Preclinical
Follow-up
Up to 1 week after removal of coarctation
Authors
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Endothelial shear adaptation time course is hypothesis-generating; leaves open human relevance and does not alter clinical practice.
Increased in vivo shear stress induces rapid redistribution of endothelial F-actin into thick central stress fibers, a process that reverses slowly over more than a week upon restoration of normal shear.
Langille et al. (1991) studied this question. Abdominal aortic coarctation (increased shear stress) vs. Control aortas was evaluated on Dynamics of redistribution of F-actin in endothelial cells. Experimentally increasing shear stress via aortic coarctation in rabbits induced rapid F-actin redistribution within 12-24 hours, which reversed slowly over 1 week after coarctation removal.
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