Key result
Hypoglycemia (3.0 mmol/liter) induced neuronal activation in the bilateral medial prefrontal cortex and thalamus, accompanied by a 6-8% decrease in quantitative cerebral blood flow.
Why the study?
Does hypoglycemia alter regional cerebral blood flow and activate the medial prefrontal cortex in normal human volunteers compared to euglycemia?
Population
9 normal human volunteers
Comparison
Hypoglycemia (3.0 ± 0.3 mmol/liter) vs Euglycemia (5.2 ± 0.2 mmol/liter)
Design
Other
Authors
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Does not warrant changes in hypoglycemia management; leaves open medial prefrontal cortex contributions to autonomic responses.
Does hypoglycemia alter regional cerebral blood flow and activate the medial prefrontal cortex in normal human volunteers compared to euglycemia?
The study demonstrates that the medial prefrontal cortex participates in autonomic responses to simple physiological stimuli like hypoglycemia in humans.
Teves et al. (2004) studied Healthy volunteers (n=9). Hypoglycemia vs. Euglycemia was evaluated on Regional cerebral blood flow (CBF). Hypoglycemia (3.0 mmol/liter) induced neuronal activation in the bilateral medial prefrontal cortex and thalamus, accompanied by a 6-8% decrease in quantitative cerebral blood flow.
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