Population
Mammals (preclinical model)
Design
Preclinical
Authors
Loading...
May inform digitalis monitoring for sequential effects; leaves open human translation from animal data.
Digitalis exerts a biphasic physiological effect on the mammalian heart, initially slowing rhythm and increasing contraction volume via vagal inhibition, followed by increased muscular irritability leading to rapid, irregular rhythms and eventual cardiac standstill.
Arthur R. Cushny (1897) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: