Randomized trial shows growth hormone stimulates bone growth in hypophysectomized rats, suggesting a direct action on growth plate cells.
Local administration of human growth hormone in vivo to the cartilage growth plate of the proximal tibia of hypophysectomized rats resulted in accelerated longitudinal bone growth. This finding suggests that growth hormone directly stimulates the cells in the growth plate, and does not support the theory that the increase in the plasma concentration of somatomedin that follows growth hormone administration is the cause of this stimulation.
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Isaksson et al. (1982) studied this question.
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