Key result
Amlodipine/valsartan combination therapy significantly reduced mean sitting diastolic blood pressure compared to amlodipine monotherapy (11.4 vs 9.3 mmHg reduction; p<0.0001).
Why the study?
Does amlodipine/valsartan combination therapy reduce blood pressure in hypertensive patients not adequately controlled on amlodipine monotherapy?
Population
944 patients with essential hypertension not adequately controlled by amlodipine monotherapy
Comparison
Amlodipine/valsartan 10/160 mg oral once daily… vs Amlodipine 10 mg oral once daily for 8 weeks
Design
RCT, randomised, double-blind
Follow-up
8 weeks
Authors
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Supports adding valsartan to amlodipine in uncontrolled hypertension; confirms additive BP reduction in this RCT population.
RCT (n=944)
double-blind
randomised
Yes
Does amlodipine/valsartan combination therapy reduce blood pressure in hypertensive patients not adequately controlled on amlodipine monotherapy?
Absolute Event Rate: 11.4% vs 9.3%
p-value: p=< 0.0001
Adding valsartan to amlodipine significantly improves blood pressure control and reduces peripheral edema compared to continuing amlodipine monotherapy in patients with uncontrolled hypertension.
Schunkert et al. (2009) conducted an RCT in essential hypertension (n=944). amlodipine/valsartan vs. amlodipine 10 mg o.d. was evaluated on change from baseline in msDBP at study endpoint (p=< 0.0001). Amlodipine/valsartan combination therapy significantly reduced mean sitting diastolic blood pressure compared to amlodipine monotherapy (11.4 vs 9.3 mmHg reduction; p<0.0001).
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