Key result
Flow cytometric measurement of P-selectin was more sensitive for early detection of platelet activation than beta-TG release in stored platelet concentrates.
Population
Stored platelet concentrates (samples from paired and unpaired units stored for 1, 3, and 5 days)
Design
Preclinical
Follow-up
5 days
Authors
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P-selectin flow cytometry may refine platelet storage monitoring in research; leaves open translation to transfusion outcomes.
Observational
Flow cytometry for P-selectin expression is a more sensitive method than beta-thromboglobulin release for detecting early platelet activation in stored platelet concentrates.
Rinder et al. (1993) conducted an observational in stored platelet concentrates. Storage of platelet concentrates was evaluated on Platelet activation (P-selectin expression and beta-TG release). Flow cytometric measurement of P-selectin was more sensitive for early detection of platelet activation than beta-TG release in stored platelet concentrates.
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