Why the study?
Which method (beta-TG release, flow cytometry, or platelet aggregometry) is most effective for detecting in vitro platelet activation?
Population
In vitro whole blood and platelet-rich plasma samples
Design
Preclinical
Authors
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Supports beta-TG release over GMP-140 for sensitivity in animal platelets; leaves open optimal assay for human platelet studies.
Which method (beta-TG release, flow cytometry, or platelet aggregometry) is most effective for detecting in vitro platelet activation?
Beta-TG release is a more sensitive marker of in vitro platelet activation than GMP-140, though flow cytometry offers practical advantages.
Matzdorff et al. (2009) studied this question.
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