Key result
P-selectin expression demonstrated higher diagnostic sensitivity for detecting in vivo platelet activation than shape change, identifying increased activation in over 80% of patients with stroke or PAD.
Why the study?
Does P-selectin expression provide higher diagnostic sensitivity for detecting in vivo platelet activation compared to shape change or fibrinogen binding in patients with stroke or PAD?
Population
Platelets in vitro, and patients with stroke or peripheral arterial disease (PAD) and controls
Comparison
Flow cytometric determination of P-selectin… vs Flow cytometric determination of shape change…
Design
Other
Authors
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P-selectin expression may be a sensitive marker for platelet activation in stroke and PAD; leaves open its therapeutic implications.
Observational
Does P-selectin expression provide higher diagnostic sensitivity for detecting in vivo platelet activation compared to shape change or fibrinogen binding in patients with stroke or PAD?
P-selectin expression is a more sensitive diagnostic marker for in vivo platelet activation than shape change, likely due to the irreversible nature of P-selectin expression upon stimulation.
Ruf et al. (1995) conducted an observational in Stroke or peripheral arterial disease (PAD). P-selectin expression determination vs. Shape change determination was evaluated on Detection of platelet activation in vivo. P-selectin expression demonstrated higher diagnostic sensitivity for detecting in vivo platelet activation than shape change, identifying increased activation in over 80% of patients with stroke or PAD.
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