Population
In vitro troponin complexes containing mutant TnI and mutant TnCs
Comparison
Disulfide cross-linking between TnI121 and TnC48… vs Uncross-linked troponin complexes
Design
Preclinical
Authors
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Provides mechanistic insight into troponin regulation; leaves open whether this interaction modulates cardiac contractility in vivo.
Disulfide cross-linking between TnI and TnC abolishes troponin's inhibitory function, demonstrating that the movement of TnI's Met121 region out of TnC's N-domain cleft is essential for regulating skeletal muscle contraction.
Luo et al. (2002) studied this question.
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