Key result
Ventricular tachypacing and atrial tachypacing produce qualitatively different temporally-evolving patterns of gene-expression change in canine models.
Why the study?
Do atrial tachypacing and ventricular tachypacing produce different time-dependent gene expression profiles in canine models?
Population
Canine models of atrial-tachycardia remodeling and congestive heart failure
Design
Preclinical
Follow-up
Up to 6 weeks
Authors
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Animal data indicate site-specific molecular responses; leaves open translation to human arrhythmia mechanisms or therapies.
Do atrial tachypacing and ventricular tachypacing produce different time-dependent gene expression profiles in canine models?
Ventricular tachypacing-induced congestive heart failure and atrial tachypacing produce qualitatively different temporally-evolving patterns of gene-expression change in canine models.
Cardin et al. (2007) studied Atrial fibrillation and congestive heart failure (n=25). Atrial tachypacing (ATP) and Ventricular tachypacing (VTP) vs. Time-dependent changes / between models was evaluated on Time-dependent mRNA expression changes. Ventricular tachypacing and atrial tachypacing produce qualitatively different temporally-evolving patterns of gene-expression change in canine models.
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