Key result
Captopril and CV 11974 shifted the pressure-natriuresis curve of transgenic rats leftward, resulting in a threefold higher sodium excretion at similar renal perfusion pressures.
Population
Transgenic rats harboring an extra mouse renin gene [TGR27] and normotensive Sprague-Dawley Hannover control…
Comparison
Infusion of the converting enzyme inhibitor… vs Normotensive Sprague-Dawley Hannover control…
Design
Preclinical
Authors
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Indicates intrarenal angiotensin II drives hypertension in this model; leaves open applicability to human disease and therapy.
p-value: p=< .05
In a transgenic rat model of hypertension, ACE inhibition and angiotensin II receptor blockade normalized the pressure-natriuresis curve, indicating that intrarenal angiotensin II mediates the rightward shift in this model.
Groß et al. (1995) studied Hypertension (Transgenic TGR(mRen-2)27 rats). Captopril or CV 11974 vs. Normotensive control rats was evaluated on Pressure-natriuresis curve and sodium excretion (p=< .05). Captopril and CV 11974 shifted the pressure-natriuresis curve of transgenic rats leftward, resulting in a threefold higher sodium excretion at similar renal perfusion pressures.
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