Key result
Oral long-acting nifedipine achieved blood pressure control significantly earlier than oral labetalol (30.4 vs 35.6 hours, p=0.041) in women with postpartum hypertension.
Why the study?
The study was conducted to compare the efficacy of oral labetalol versus oral nifedipine for the treatment of postpartum hypertension.
Does oral labetalol improve blood pressure control compared to oral long-acting nifedipine in patients with postpartum hypertension?
RCT (n=124)
Open-label
Simple randomization
No
Does oral labetalol improve blood pressure control compared to oral long-acting nifedipine in patients with postpartum hypertension?
Absolute Event Rate: 30.4% vs 35.6%
p-value: p=0.041
Oral long-acting nifedipine achieves blood pressure control significantly faster than oral labetalol in patients with postpartum hypertension.
Nifedipine may be prioritized over labetalol for faster postpartum BP control; extends direct RCT comparisons of oral antihypertensives.
Objective: To compare the efficacy of oral Labetalol versus oral Nifedipine for the treatment of postpartum hypertension. Methods: A prospective randomized controlled trial with parallel assignment was conducted in the department of Obstetrics and Gynecology, Dow University of Health Sciences Karachi, Pakistan, 124 patients with post partum hypertension were selected and randomized into two groups with 62 patients receiving Labetalol and 62 receiving long acting nifedipine. Initial blood pressures were recorded, and the respective drug was administered. Dose adjustments were performed in the initial 24 hours. The outcome was measured in the form of drug efficacy by lowering of systolic blood pressure less than 140mm of Hg and diastolic less than 90mm of Hg up to 48 hours after starting treatment. Data was entered and analyzed through SPSS version 20. Results: Our study randomized 62 women to oral labetalol and 62 women to oral long acting nifedipine. The time required to achieve blood pressure control was 35.6±2.8 hours in labetalol group and 30.4±1.9 hours in nifedipine group (p=0.04).length of hospital stay, need of additional antihypertensive medications were same in both groups. Minor side effects were observed more in nifedipine group. Conclusion: We conclude that both oral labetalol and oral long acting nifedipine are effective and well tolerated interventions for the management of post-partum hypertension. However we found Nifidipine more effective in the management of postpartum hypertension. doi: https://doi.org/10.12669/pjms.35.5.812 How to cite this:Ainuddin J, Javed F, Kazi S. Oral labetalol versus oral nifedipine for the management of postpartum hypertension a randomized control trial. Pak J Med Sci. 2019;35(5):1428-1433. doi: https://doi.org/10.12669/pjms.35.5.812 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
No takes yet. Share an insight, caveat, or question.
Ainuddin et al. (2019) conducted an RCT in Postpartum hypertension (n=124). Oral long-acting nifedipine vs. Oral labetalol (100 mg starting dose, increased up to 1200 mg as needed) was evaluated on Time required to achieve blood pressure control (SBP < 150mmHg and DBP 80-100mmHg) in hours (p=0.041). Oral long-acting nifedipine achieved blood pressure control significantly earlier than oral labetalol (30.4 vs 35.6 hours, p=0.041) in women with postpartum hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: