Key result
Oral labetalol resulted in a similar time to achieve blood pressure control compared to oral extended release nifedipine (37.6 vs 38.2 hours, p=0.51) for persistent postpartum hypertension.
Why the study?
Does oral labetalol reduce the time to sustained blood pressure control compared to oral extended release nifedipine in women with persistent postpartum hypertension?
RCT (n=50)
Does oral labetalol reduce the time to sustained blood pressure control compared to oral extended release nifedipine in women with persistent postpartum hypertension?
Absolute Event Rate: 37.6% vs 38.2%
p-value: p=0.51
Oral labetalol and extended-release nifedipine are similarly effective for achieving blood pressure control in persistent postpartum hypertension, but labetalol achieves control more often with the starting dose and has fewer minor side effects.
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Both agents achieve equivalent BP control postpartum; supports either as first-line and extends RCT data on agent selection.
Sharma et al. (2016) conducted an RCT in persistent postpartum hypertension (n=50). Oral labetalol vs. Oral extended release nifedipine was evaluated on time to sustained blood pressure control defined as the absence of severe hypertension for at least 12 hours (p=0.51). Oral labetalol resulted in a similar time to achieve blood pressure control compared to oral extended release nifedipine (37.6 vs 38.2 hours, p=0.51) for persistent postpartum hypertension.
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