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January 1, 2001Diseases of the Colon & Rectum

Abdominoperineal resection for rectal cancer at a specialty center

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Authors

ANAviram NissanJGJosé G. GuillemPPPhilip B. Paty

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Overview

Prospective analysis evaluates postoperative complications in rectal cancer patients receiving neoadjuvant therapy, indicating important treatment implications.

Key Points

  • This study evaluates postoperative complications in rectal cancer patients requiring abdominoperineal resection, particularly concerning neoadjuvant therapy.
  • Reviewed a prospective database of 5,634 patients from 1987-1997 at Memorial Sloan-Kettering Cancer Center.
  • Identified 292 patients who underwent abdominoperineal resection due to primary rectal adenocarcinoma.
  • Compared outcomes among groups receiving neoadjuvant radiotherapy, postoperative adjuvant radiotherapy, and no radiotherapy.
  • Operative duration was significantly longer in the neoadjuvant (P=0.01) and intraoperative radiotherapy groups (P<0.0001) compared to the nonradiotherapy group.
  • Early postoperative complications were significantly higher in the neoadjuvant radiotherapy groups compared to the nonradiotherapy group.
  • No significant differences in late complications, overall survival, disease-free survival, and local recurrence were found among the groups.

Cite This Study

Nissan et al. (2001) studied this question.

synapsesocial.com/papers/6a2035adeab213b7bb295447https://doi.org/10.1007/bf02234816
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