What question did this study set out to answer?

To evaluate the efficacy, toxicity profile, and sphincter preservation rates of preoperative chemoradiation followed by aggressive surgical resection in patients with locally advanced rectal cancer.

November 1, 2003Seminars in Surgical Oncology

Preoperative chemoradiation for locally advanced rectal cancer: rationale, technique, and results of treatment

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Authors

CCChristopher H. Crane JSJohn M. Skibber

Discussion

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Overview

Cohort study demonstrates high sphincter preservation and pelvic control in locally advanced rectal cancer, highlighting the benefit of combined multimodal therapy.

Key Points

To evaluate the efficacy, toxicity profile, and sphincter preservation rates of preoperative chemoradiation followed by aggressive surgical resection in patients with locally advanced rectal cancer.
Retrospective review of 392 patients with stage II and III rectal cancer, alongside metastatic cases, treated over a 10-year period at M. D. Anderson Cancer Center.
Treatment entailed neoadjuvant pelvic chemoradiation followed by surgeries including total mesorectal excision, coloanal anastomosis, and multivisceral resection, paired with active bowel and skin care protocols.
Neoadjuvant chemoradiation followed by surgery achieved high rates of pelvic control and sphincter preservation with low rates of acute, perioperative, and late morbidity.
Sphincter preservation rates increased during the final 3 years due to coloanal anastomosis utilization for low tumors, without increasing pelvic recurrence or perioperative complications.
Tumor non-responsiveness to preoperative therapy, poor differentiation, and clinical T4 stage were qualitative predictors of significantly worse pelvic control and overall survival.

Cite This Study

Crane et al. (2003) studied this question.

synapsesocial.com/papers/6ab1cdc75e56d22700de3956 https://doi.org/10.1002/ssu.10046

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November 1, 2003Seminars in Surgical Oncology

Preoperative chemoradiation for locally advanced rectal cancer: rationale, technique, and results of treatment

View Full Paper

Ask AI

Bookmark

Authors

CCChristopher H. Crane JSJohn M. Skibber

Discussion

Member takes

Overview

Cohort study demonstrates high sphincter preservation and pelvic control in locally advanced rectal cancer, highlighting the benefit of combined multimodal therapy.

Key Points

To evaluate the efficacy, toxicity profile, and sphincter preservation rates of preoperative chemoradiation followed by aggressive surgical resection in patients with locally advanced rectal cancer.
Retrospective review of 392 patients with stage II and III rectal cancer, alongside metastatic cases, treated over a 10-year period at M. D. Anderson Cancer Center.
Treatment entailed neoadjuvant pelvic chemoradiation followed by surgeries including total mesorectal excision, coloanal anastomosis, and multivisceral resection, paired with active bowel and skin care protocols.
Neoadjuvant chemoradiation followed by surgery achieved high rates of pelvic control and sphincter preservation with low rates of acute, perioperative, and late morbidity.
Sphincter preservation rates increased during the final 3 years due to coloanal anastomosis utilization for low tumors, without increasing pelvic recurrence or perioperative complications.
Tumor non-responsiveness to preoperative therapy, poor differentiation, and clinical T4 stage were qualitative predictors of significantly worse pelvic control and overall survival.

Cite This Study

Crane et al. (2003) studied this question.

synapsesocial.com/papers/6ab1cdc75e56d22700de3956 https://doi.org/10.1002/ssu.10046

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