What question did this study set out to answer?

To evaluate the incidence of postoperative complications and identify predictive clinicopathologic factors in patients undergoing preoperative combined modality therapy followed by radical resection for locally advanced rectal cancer.

May 27, 2005Journal of the American College of Surgeons

Complications after Preoperative Combined Modality Therapy and Radical Resection of Locally Advanced Rectal Cancer: A 14-Year Experience from a Specialty Service

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Authors

DCDavid B. Chessin WEWarren E. Enker ACAlfred M. Cohen

Discussion

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Overview

Cohort study observes major postoperative complications in one-third of rectal cancer patients after chemoradiotherapy, indicating baseline comorbidity is the primary risk driver.

Key Points

To evaluate the incidence of postoperative complications and identify predictive clinicopathologic factors in patients undergoing preoperative combined modality therapy followed by radical resection for locally advanced rectal cancer.
Reviewed a prospectively maintained database of 297 consecutive patients with locally advanced rectal adenocarcinoma (T3-4 and/or N1) treated with preoperative chemoradiation (5,040 cGy and 5-FU) followed by surgery.
Tracked major postoperative complications, defined as events requiring medical or surgical intervention, over a median follow-up of 43.9 months (range 0.8 to 128.6 months).
Zero 30-day postoperative mortalities occurred, but 145 major complications developed in 33% of patients (98/297), predominantly small bowel obstruction (11%, n=32) and wound infection (10%, n=31).
Among 210 patients receiving low anterior resection, anastomotic leaks occurred in 4% (n=8) and pelvic abscesses occurred in 4% (n=9).
Preoperative comorbidity was the only clinicopathologic factor significantly associated with complications (p = 0.02), while complications had no significant effect on long-term oncologic outcomes.

Cite This Study

Chessin et al. (2005) studied this question.

synapsesocial.com/papers/6a701e35ac440176ef28c334 https://doi.org/10.1016/j.jamcollsurg.2005.02.027

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May 27, 2005Journal of the American College of Surgeons

Complications after Preoperative Combined Modality Therapy and Radical Resection of Locally Advanced Rectal Cancer: A 14-Year Experience from a Specialty Service

View Full Paper

Ask AI

Bookmark

Authors

DCDavid B. Chessin WEWarren E. Enker ACAlfred M. Cohen

Discussion

Member takes

Overview

Cohort study observes major postoperative complications in one-third of rectal cancer patients after chemoradiotherapy, indicating baseline comorbidity is the primary risk driver.

Key Points

To evaluate the incidence of postoperative complications and identify predictive clinicopathologic factors in patients undergoing preoperative combined modality therapy followed by radical resection for locally advanced rectal cancer.
Reviewed a prospectively maintained database of 297 consecutive patients with locally advanced rectal adenocarcinoma (T3-4 and/or N1) treated with preoperative chemoradiation (5,040 cGy and 5-FU) followed by surgery.
Tracked major postoperative complications, defined as events requiring medical or surgical intervention, over a median follow-up of 43.9 months (range 0.8 to 128.6 months).
Zero 30-day postoperative mortalities occurred, but 145 major complications developed in 33% of patients (98/297), predominantly small bowel obstruction (11%, n=32) and wound infection (10%, n=31).
Among 210 patients receiving low anterior resection, anastomotic leaks occurred in 4% (n=8) and pelvic abscesses occurred in 4% (n=9).
Preoperative comorbidity was the only clinicopathologic factor significantly associated with complications (p = 0.02), while complications had no significant effect on long-term oncologic outcomes.

Cite This Study

Chessin et al. (2005) studied this question.

synapsesocial.com/papers/6a701e35ac440176ef28c334 https://doi.org/10.1016/j.jamcollsurg.2005.02.027

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