Key result
In patients aged ≥60 years with recent ischemic stroke, pulse pressure was significantly associated with combined recurrent vascular events and mortality (HR 1.35; 95% CI 1.18-1.54).
Why the study?
Is pulse pressure within 3 months after ischemic stroke associated with long-term stroke outcomes in patients with first-ever ischemic stroke?
Cohort (n=4,195)
Is pulse pressure within 3 months after ischemic stroke associated with long-term stroke outcomes in patients with first-ever ischemic stroke?
Hazard Ratio: 1.35 (95% CI 1.18–1.54)
Pulse pressure measured within 3 months after an ischemic stroke is a significant predictor of long-term recurrent vascular events and mortality, particularly in patients aged 60 years or older.
May refine post-stroke prognosis in older adults; leaves open whether modification improves outcomes.
BACKGROUND: Pulse pressure (PP) is a surrogate marker of arterial stiffness. Studies on baseline PP and long-term outcomes in patients with stroke are limited. We aimed to evaluate whether PP within 3 months after ischemic stroke was associated with long-term stroke outcomes. METHODS: A total of 4,195 patients (61.2 ± 11.6 years, 68.4% men) with first-ever ischemic stroke in 3 months had baseline blood pressure (BP) measured. Study end-points were the combined end-points (recurrent vascular events and all-cause mortality) and recurrent stroke. RESULTS: In the group <60 years of age, the BP components of systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), or PP did not significantly correlate with long-term stroke outcomes. In the group ≥60 years of age, PP was significantly associated with combined end-points (hazards ratio [HR] = 1.35; 95% confidence interval [CI], 1.18-1.54) and recurrent stroke (HR = 1.46; 95% CI, 1.24-1.72). Combination of SBP and PP, DBP and PP, or MAP and PP, respectively, showed no incremental value of SBP, DBP, or MAP in predicting long-term stroke outcomes. CONCLUSIONS: PP was significantly associated with long-term stroke outcomes, and this association was prominent in patients with stroke older than 60 years of age.
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Su et al. (2017) conducted a cohort in first-ever ischemic stroke (n=4,195). Pulse pressure was evaluated on Combined end-points (recurrent vascular events and all-cause mortality) (HR 1.35, 95% CI 1.18-1.54). In patients aged ≥60 years with recent ischemic stroke, pulse pressure was significantly associated with combined recurrent vascular events and mortality (HR 1.35; 95% CI 1.18-1.54).
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