What question did this study set out to answer?

To evaluate the relationship between continuous blood pressure monitoring parameters during the acute phase of stroke and long-term mortality risk.

Pulse Pressure in Acute Stroke Is an Independent Predictor of Long-Term Mortality

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Why the study?

Does 24-hour pulse pressure predict 1-year mortality in patients with acute stroke?

To evaluate the relationship between continuous blood pressure monitoring parameters during the acute phase of stroke and long-term mortality risk.
Monitored 24-hour blood pressure parameters starting within 24 hours of ictus in a consecutive cohort of 198 patients presenting with first-ever acute stroke.
Identified independent predictors of 1-year mortality using multivariate Cox proportional hazards regression analysis.
At 1-year post-stroke follow-up, 34 of 198 patients (17.7%) had died.
Each 10 mm Hg elevation in 24-hour pulse pressure was independently associated with heightened 1-year mortality (HR 1.39, 95% CI: 1.04–1.86, p = 0.028).
Multivariate analysis also confirmed age, level of consciousness on hospital admission, and lacunar stroke as significant independent predictors of 1-year survival.

Does 24-hour pulse pressure predict 1-year mortality in patients with acute stroke?

Population

198 consecutive first-ever acute stroke patients

Intervention

24-hour pulse pressure (24-hour PP) measured via BP monitoring initiated within 24 h of ictus

Outcome

1-year mortalityhard clinical

Increasing 24-hour pulse pressure in acute stroke patients is independently associated with higher 1-year mortality.

No takes yet. Share an insight, caveat, or question.

May refine post-stroke mortality risk stratification; leaves open whether PP modification improves outcomes.

Vemmos et al. (2004) studied this question.

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