Prodrug Activation Gated by a Molecular “OR” Logic Trigger

Molecules that define logic: A molecular “OR” logic gate trigger has been demonstrated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500842_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.