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January 1, 1978Journal of Applied Physiology

Effect of acute and established anemia on O2 transport at rest, submaximal and maximal work

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Why the study?

Does acute and maintained isovolemic anemia affect oxygen transport and exercise capacity in normal males?

Population

Normal males

Comparison

Acute and maintained isovolemic anemia vs Baseline

Design

Other

Follow-up

10-14 days

Authors

RWRobert D. WoodsonUniversity of MinnesotaRWRobert E. WillsUnited States Department of Veterans AffairsCLClaude LenfantBoston University

Discussion

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Implication

Anemia may confound exercise testing interpretation in healthy adults; leaves open effects in cardiovascular disease populations.

Structured PICO

Does acute and maintained isovolemic anemia affect oxygen transport and exercise capacity in normal males?

P
Population
Normal males
I
Intervention
Acute and maintained isovolemic anemia (34% reduction in hemoglobin concentration)
C
Comparator
Baseline (control values prior to hemoglobin reduction)
O
Outcome
Oxygen transport during rest and exercisesurrogate

Acute and established isovolemic anemia decreases maximal exercise capacity and VO2 max proportionally to hemoglobin reduction, despite compensatory physiological mechanisms such as increased cardiac output and 2,3-DPG.

Cite This Study

Woodson et al. (1978) studied this question.

synapsesocial.com/papers/6a203b89cb26ec8ce28fd3cbhttps://doi.org/10.1152/jappl.1978.44.1.36
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of long-term anemia and retransfusion on central circulation during exercise1986 · 35 citations
  2. 2Cardiovascular responses to dynamic exercise with acute anemia in humans1997 · 92 citations
  3. 3Central circulation during exercise after venesection and reinfusion of red blood cells1976 · 173 citations
  4. 4Blunted Hemodynamic Response and Reduced Oxygen Delivery With Exercise in Anemic Heart Failure Patients With Systolic Dysfunction2007 · 7 citations
  5. 5The physiologic reserve in oxygen carrying capacity: studies in experimental hemodilution1986 · 147 citations