Key result
Anemic heart failure patients with systolic dysfunction had significantly lower peak exercise oxygen consumption compared to non-anemic patients (11.7 vs 13.4 mL/min/kg; P=.01).
Why the study?
Does anemia worsen peak exercise oxygen consumption and hemodynamics in heart failure patients with systolic dysfunction?
Observational (n=209)
Does anemia worsen peak exercise oxygen consumption and hemodynamics in heart failure patients with systolic dysfunction?
Anemic heart failure patients with systolic dysfunction exhibit a blunted hemodynamic response to exercise, which may contribute to their reduced exercise tolerance.
Anemia linked to reduced exercise capacity in systolic HF; hypothesis-generating for correction trials before practice change.
Anemic heart failure patients with systolic dysfunction are known to have reduced exercise capacity. Whether this is related to poor hemodynamic adaptation to anemia is not known. Peak exercise oxygen consumption (VO2) and hemodynamics at rest and peak exercise were assessed among 209 patients and compared among those who were (n=90) and were not (n=119) anemic. Peak VO2 was significantly lower among anemic patients (11.7+/-3.3 mL/min/kg vs 13.4+/-3.1 mL/min/kg; P=.01). At rest, right atrial pressure was higher (10+/-5 mm Hg vs 8+/-4 mm Hg; P=.02) and venous oxygen saturation lower (62%+/-8% vs 58%+/-10%; P<.01) among anemic patients. At peak exercise, anemic patients had a higher wedge pressure (27+/-9 mm Hg vs 24+/-10 mm Hg; P=.04). No significant differences in stroke volume, cardiac index, systemic vascular resistance, or oxygen saturation were noted between the 2 groups. In conclusion, the relative hemodynamic response to exercise among anemic heart failure patients appears blunted and may contribute to worse exercise tolerance.
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Listerman et al. (2007) conducted an observational in Heart failure with systolic dysfunction (n=209). Anemia vs. No anemia was evaluated on Peak exercise oxygen consumption (VO2) (p=.01). Anemic heart failure patients with systolic dysfunction had significantly lower peak exercise oxygen consumption compared to non-anemic patients (11.7 vs 13.4 mL/min/kg; P=.01).
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