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April 1, 1969CirculationOpen Access

The Hemodynamic Response to Chronic Anemia

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Why the study?

Do physiological and pharmacological interventions reverse the hyperkinetic circulatory response in patients with chronic anemia?

Population

24 patients with chronic anemia

Comparison

Physiological and pharmacological interventions vs Baseline hemodynamic state (before intervention)

Design

Case_series

Authors

MDMartin DukeWAWalter H. Abelmann

Discussion

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Overview

Acute vasoconstriction reverses hyperkinetic circulation in anemia; leaves open therapeutic role in chronic management.

Structured PICO

Do physiological and pharmacological interventions reverse the hyperkinetic circulatory response in patients with chronic anemia?

P
Population
24 patients with chronic anemia
I
Intervention
Physiological and pharmacological interventions (treatment of anemia, 100% oxygen inhalation, orthostatic stress, methoxamine administration)
C
Comparator
Baseline hemodynamic state (before intervention)
O
Outcome
Changes in cardiac output and hemodynamic parameters (central blood volume, total systemic resistance, stroke index, cardiac index, mean arterial blood pressure)surrogate

The hyperkinetic circulatory response to chronic anemia is labile and can be acutely reversed by peripheral vasoconstriction induced by orthostatic stress or pressor amines.

Cite This Study

Duke et al. (1969) studied this question.

synapsesocial.com/papers/6a76d06fd8eb58afc2bd6cd8https://doi.org/10.1161/01.cir.39.4.503
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Also Consider

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  1. 1CARDIOPULMONARY PHYSIOLOGICAL RESPONSES TO HEAVY EXERCISE IN PATIENTS WITH ANEMIA *1960 · 147 citations
  2. 2A Humoral Influence on Cardiovascular Adjustments to Acute and Chronic Posthemorrhagic Anemia in Dogs1957 · 21 citations
  3. 3The Hyperkinetic Heart Syndrome1962 · 122 citations
  4. 4An Improved Cuvette Densitometer for Cardiac Output Determination by the Dye-Dilution Method1953 · 77 citations
  5. 5Effect of Hematocrit on Venous Return1961 · 226 citations