Key result
In patients with cardiac sarcoidosis, late gadolinium enhancement on cardiac MRI was present in all patients' basal septal walls and most frequently involved the subepicardial layer.
Why the study?
What are the most common sites and layer patterns of late gadolinium enhancement on cardiac MR images in patients with cardiac sarcoidosis?
Observational (n=9)
Single-blind
No
What are the most common sites and layer patterns of late gadolinium enhancement on cardiac MR images in patients with cardiac sarcoidosis?
In patients with cardiac sarcoidosis, late gadolinium enhancement on cardiac MRI is most frequently observed in the basal septal wall and the subepicardial layer.
Answers are grounded in this paper and cite their sources.
Basal septal subepicardial LGE may aid cardiac sarcoidosis diagnosis; small case series leaves open broader applicability and outcome prediction.
Cardiac sarcoidosis (CS) can cause sudden death, which is the leading cause of mortality in patients with sarcoidosis in Japan. However, it is difficult to diagnose CS because of the lack of a sensitive diagnostic method for the condition. Late gadolinium-enhanced cardiac magnetic resonance (MR) imaging demonstrates improved sensitivity for diagnosing CS. Therefore, it is important to know the late gadolinium-enhancement (LGE) characteristics of CS on cardiac MR images in order to diagnose CS accurately. In this study, we investigated the most common sites of LGE on cardiac MR images in CS. Late gadolinium-enhanced MR images of 9 consecutive patients with CS (obtained between August 2009 and July 2015) were reviewed by two radiologists. The distribution of LGE was evaluated using the American Heart Association 17-segment model of the left ventricle. The LGE in each segment was also classified into 4 patterns according to the myocardial layer in which it occurred (the subepicardial, subendocardial, intramural, and transmural layer patterns). All 9 patients exhibited LGE in their left ventricle, and 70 of 153 (46%) myocardial segments were enhanced. All of the patients displayed LGE in the basal septal wall. The patients' LGE layer patterns were as follows: subepicardial: 40% (28/70), intramural: 30% (21/70), subendocardial: 16% (11/70), and transmural: 14% (10/70). The basal septum wall and subepicardial layer often exhibit LGE on cardiac MR images in CS patients. LGE can be observed in other segments and layers in some cases.
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Komada et al. (2016) conducted an observational in Cardiac sarcoidosis (n=9). Late gadolinium-enhanced cardiac magnetic resonance imaging was evaluated on Distribution and layer patterns of late gadolinium enhancement in myocardial segments. In patients with cardiac sarcoidosis, late gadolinium enhancement on cardiac MRI was present in all patients' basal septal walls and most frequently involved the subepicardial layer.
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