Key result
Late gadolinium enhancement in the right ventricular free wall was associated with sustained ventricular tachycardia in patients with cardiac sarcoidosis.
Why the study?
Although late gadolinium enhancement (LGE) on CMR is associated with sustained ventricular tachycardia (sVT) in cardiac sarcoidosis, the relationship between LGE localization and sVT has not been fully evaluated.
Is late gadolinium enhancement in the right ventricular free wall associated with sustained ventricular tachycardia in patients with cardiac sarcoidosis?
Observational (n=31)
No
Is late gadolinium enhancement in the right ventricular free wall associated with sustained ventricular tachycardia in patients with cardiac sarcoidosis?
Answers are grounded in this paper and cite their sources.
In patients with cardiac sarcoidosis, late gadolinium enhancement in the right ventricular free wall on CMR is strongly associated with sustained ventricular tachycardia.
Sustained ventricular tachycardia (sVT), leading to sudden cardiac death, is one of the common manifestations in cardiac sarcoidosis (CS). Although late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) has been reported to be associated with sVT, the relationships of its localization to sVT have not been fully evaluated.To evaluate the localization of LGE and its relationships to sVT in patients with CS, we reviewed medical record of consecutive 31 patients with CS who underwent CMR. The localization of LGE was divided into four categories: Left ventricular (LV) septum, LV free wall, right ventricular (RV) septum, and RV free wall. We investigated the association of sVT with localization of LGE and other parameters including serum biomarkers LV ejection fraction on echocardiography and Fluorine-18-fluorodeoxyglucose (FDG) accumulation on positron emission tomography (PET) -CT.Of the studied population, 8 patients (25.8%) were known to present with sVT among 31 CS patients. LGE was observed in the RV free wall in 6 patients with sVT, whereas it was in 5 patients without sVT (75.0% versus 21.7%, P = 0.022). Univariate analysis showed that only LGE in the RV free wall was associated with sVT (odds ratio [OR]: 10.80; 95% confidence interval [CI]: 1.64-70.93, P = 0.013).LGE in the RV free wall was associated with sVT in patients with CS.
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Yodogawa et al. (2022) conducted an observational in Cardiac sarcoidosis (n=31). Late gadolinium enhancement in the right ventricular free wall vs. Absence of late gadolinium enhancement in the right ventricular free wall was evaluated on Sustained ventricular tachycardia (sVT) (OR 10.80, 95% CI 1.64-70.93, p=0.013). Late gadolinium enhancement in the right ventricular free wall was associated with sustained ventricular tachycardia in patients with cardiac sarcoidosis.
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