Protein corona as the key factor governing the in vivo fate of magnetic nanoparticles

Ashish Avasthi; Yilian Fernández‐Afonso; Lucía Gutiérrez; Jesús M. de la Fuente; Manuel Pernía Leal; Carlos Caro; Maria Luisa García‐Martín

doi:10.1039/d5bm00387c

January 1, 2025Biomaterials Science

Protein corona as the key factor governing the in vivo fate of magnetic nanoparticles

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Key Points

This research focuses on how the protein corona impacts the behavior of iron oxide nanoparticles in biological systems.
Analyzed the influence of protein corona on biodistribution
Evaluated the uptake rate and bioavailability of iron oxide nanoparticles
Compared effects based on core size and hydrodynamic diameter.
Protein corona composition was identified as crucial for biodistribution patterns.
Uptake rates varied significantly based on the protein corona rather than nanoparticle size.
Bioavailability was notably affected by the protein corona, indicating its key role.

Implication

Reveals the impact of protein corona on biodistribution and uptake of nanoparticles, suggesting its importance in nanoparticle design.

Abstract

The protein corona composition, rather than core size or hydrodynamic diameter, predominantly determines the biodistribution, uptake rate, and bioavailability of iron oxide nanoparticles.

Discussion

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Cite This Study

Avasthi et al. (2025) studied this question.

synapsesocial.com/papers/6a205677e9ca693ff1e72cfc https://doi.org/10.1039/d5bm00387c

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Protein corona as the key factor governing the in vivo fate of magnetic nanoparticles

Key Points

Implication

Abstract

Discussion

Cite This Study

Protein corona as the key factor governing the in vivo fate of magnetic nanoparticles

Key Points

Implication

Abstract

Discussion

Cite This Study

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