Key result
ZP123 did not affect the inducibility of ischemia-induced focal ventricular tachycardia compared to saline at any plasma concentration (e.g., 77% vs 75% at 0.8 nM).
Why the study?
Does ZP123 reduce the inducibility of ischemia-induced focal ventricular tachycardia and triggered activity in dogs with coronary artery occlusion?
RCT (n=26)
randomly assigned
Does ZP123 reduce the inducibility of ischemia-induced focal ventricular tachycardia and triggered activity in dogs with coronary artery occlusion?
Pharmacological stimulation of gap junction intercellular communication with ZP123 does not prevent ischemia-induced focal ventricular tachycardia or triggered activity in a canine model.
No takes yet. Share an insight, caveat, or question.
Negative canine ischemia model result does not support gap junction stimulation for focal VT; leaves open human translation.
Xing et al. (2005) conducted an RCT in Ischemia-induced focal ventricular tachycardia (n=26). ZP123 vs. Saline was evaluated on Inducibility of focal ventricular tachycardia. ZP123 did not affect the inducibility of ischemia-induced focal ventricular tachycardia compared to saline at any plasma concentration (e.g., 77% vs 75% at 0.8 nM).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: