Key result
ZP123 dose-dependently prevented metabolic stress-induced atrial conduction velocity slowing at doses ranging from 1 nM to 10 microM, without affecting conduction during physiological conditions.
Why the study?
Does ZP123 prevent atrial conduction slowing during metabolic stress in isolated rat atria?
Does ZP123 prevent atrial conduction slowing during metabolic stress in isolated rat atria?
The antiarrhythmic peptide analog ZP123 selectively prevents atrial conduction slowing during metabolic stress in rat atria without affecting normal conduction or major ion channels.
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Hypothesis-generating for selective antiarrhythmic peptides under metabolic stress; human studies required before clinical consideration.
Haugan et al. (2005) studied Atrial conduction slowing during metabolic stress. ZP123 was evaluated on Metabolic stress-induced atrial conduction velocity slowing. ZP123 dose-dependently prevented metabolic stress-induced atrial conduction velocity slowing at doses ranging from 1 nM to 10 microM, without affecting conduction during physiological conditions.
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