Key result
Zatebradine reduces heart rate and blocks cardiac sodium channels in a frequency- and voltage-dependent manner.
Why the study?
The electromechanical effects of zatebradine on cardiac rate, contractility, and action potentials in isolated cardiac preparations were studied to characterize its pharmacological profile.
Population
Isolated guinea pig atria and ventricular papillary muscles
Comparison
Effects of varying concentrations of zatebradine on cardiac parameters
Design
Experimental study on isolated cardiac tissues
Authors
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Zatebradine's atrial effects in guinea pig tissue warrant in vivo testing; leaves open any clinical role in rate control.
Pérez et al. (1995) studied Isolated guinea pig cardiac preparations. Zatebradine was evaluated on Rate, contractile force, and transmembrane action potentials. Zatebradine produced a negative chronotropic effect (IC50 = 6.5 ± 3.0 x 10^-6 M) and a frequency- and voltage-dependent block of Na+ channels in isolated guinea pig cardiac preparations.
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