Why the study?
Does zatebradine block the pacemaker current I(f) in isolated rabbit sinoatrial node cells?
Population
Isolated rabbit sinoatrial (SA) node cells
Design
Preclinical
Authors
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Supports selective I(f) blockade as a bradycardic mechanism in preclinical models; leaves open clinical translation and safety.
Does zatebradine block the pacemaker current I(f) in isolated rabbit sinoatrial node cells?
Zatebradine reduces heart rate via use-dependent block of the I(f) pacemaker current, identifying it as a novel I(f) blocker.
Goethals et al. (1993) studied this question.
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