What question did this study set out to answer?

The study aims to compare the effects of cilobradine and zatebradine on the cardiac pacemaker current (If).

October 1, 2003European Journal of PharmacologyOpen Access

Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine

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Population

Short Purkinje fibres from sheep hearts and isolated rabbit sino-atrial cells

Comparison

Cilobradine (DK-AH269) and zatebradine (UL-FS49) vs Comparison between cilobradine and zatebradine

Design

Preclinical

Authors

PBP.P. Van BogaertUniversity of Antwerp FPFrançois PittoorsUniversity of Antwerp

Discussion

Member takes

Implication

Cilobradine may offer advantages in If inhibition; leaves open clinical translation from animal models.

Key Points

The study aims to compare the effects of cilobradine and zatebradine on the cardiac pacemaker current (If).
Short Purkinje fibres from sheep hearts and isolated rabbit sino-atrial cells used.
Two-microelectrode voltage-clamp and patch clamp techniques employed.
Dose-dependency of If amplitude was assessed with voltage-clamp pulse trains.
Cilobradine demonstrated a stronger and faster use-dependent blockade of If compared to zatebradine.
Recovery from blockade was significantly faster with zatebradine during prolonged hyperpolarization.
Cilobradine effectively reduced the pacemaker diastolic depolarization rate and cell firing frequency.

Structured PICO

Population

Short Purkinje fibres from sheep hearts and isolated rabbit sino-atrial cells

Intervention

Cilobradine (DK-AH269) and zatebradine (UL-FS49)

Comparator

Comparison between cilobradine and zatebradine

Outcome

Action on the cardiac pacemaker current (If) amplitude, voltage dependence, and kinetics of channel activationsurrogate

Cilobradine is a more potent and faster use-dependent blocker of the cardiac pacemaker current (If) compared to zatebradine in preclinical models.

Cite This Study

Bogaert et al. (2003) studied this question.

synapsesocial.com/papers/6a7bbb032305edf9bbed203c https://doi.org/10.1016/j.ejphar.2003.08.083

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Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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