Why the study?
Does ZD7288 inhibit the hyperpolarization activated inward current (If) in guinea-pig sinoatrial node cells?
Population
Single, freshly dissociated guinea-pig sinoatrial node (SAN) cells
Comparison
ZENECA ZD7288 (4--1,2-dimethyl-6- pyridinium… vs Alinidine and UL-FS 49 (zatebradine)
Design
Preclinical
Authors
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May explain selective bradycardia via If inhibition in animal SAN cells; leaves open human translation and therapeutic utility.
Does ZD7288 inhibit the hyperpolarization activated inward current (If) in guinea-pig sinoatrial node cells?
ZD7288 selectively inhibits the pacemaker current (If) in sinoatrial node cells by altering its activation characteristics, explaining its selective bradycardic properties.
BoSmith et al. (1993) studied this question.
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