Why the study?
Does zatebradine attenuate positive chronotropic and inotropic responses to cyclic AMP-related substances in isolated dog atria?
Population
Isolated, blood-perfused dog atria
Comparison
Zatebradine (0.03-1 mumol) vs Control (responses without zatebradine)
Design
Preclinical
Authors
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May inform I(f) inhibitor selectivity in isolated atria; leaves open translation to human physiology or clinical rate control.
Does zatebradine attenuate positive chronotropic and inotropic responses to cyclic AMP-related substances in isolated dog atria?
Zatebradine selectively attenuates positive chronotropic but not inotropic responses to cyclic AMP-related substances in dog atria, likely via I(f) inhibition rather than ICa inhibition.
Sawaki et al. (1995) studied this question.
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